Vol. 6 No. 04 (2025), FS
Vol. 6 No. 04 (2025)

DEGENERATIVE ENCEPHALOPATHY ASSOCIATED WITH SENILITY IN AN ELDERLY DOG: A CASE REPORT

FS
Published 02/12/2025
Ayla Pessoa Rodrigues
Acadêmica em Medicina Veterinária, Centro Universitário dos Guararapes - UNIFG
Iacoan Wallison Diniz da Silva
Acadêmico em Medicina Veterinária, Centro Universitário dos Guararapes - UNIFG
Raíssa Camila Barros da Silva
Acadêmica em Medicina Veterinária, Centro Universitário dos Guararapes - UNIFG
Beto Cherles Coral Rodrigues
Pós - Graduado em Oncologia Veterinária, Faculdade Unyleya
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Keywords

geriatric dogs, brain degeneration, canine cognitive dysfunction, necropsy, animal welfare.

How to Cite

Pessoa Rodrigues, A. ., Wallison Diniz da Silva, I. ., Camila Barros da Silva, R. ., & Cherles Coral Rodrigues, B. . (2025). DEGENERATIVE ENCEPHALOPATHY ASSOCIATED WITH SENILITY IN AN ELDERLY DOG: A CASE REPORT. Journal of Interdisciplinary Debates, 6(04), 113-123. https://doi.org/10.51249/jid.v6i04.2737
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Abstract

Aging in dogs is associated with morphofunctional changes in the central nervous system (CNS), including cortical atrophy, neuronal loss, and the accumulation of pigments such as lipofuscin, similar to those observed in human neurodegenerative diseases. Among these conditions, Canine Cognitive Dysfunction Syndrome (CCDS) and senile brain degeneration stand out as frequent causes of neurological disorders in geriatric dogs. This paper reports the case of a male, mixed-breed dog, approximately 16 years old, that presented with progressive disorientation, ataxia, seizures, and behavioral changes. Given the clinical deterioration and lack of a favorable prognosis, humane euthanasia was chosen, followed by necropsy for diagnostic confirmation. Macroscopic and histopathological evaluation revealed diffuse cortical atrophy, white matter rarefaction, and reactive gliosis, consistent with advanced senile brain degeneration. This case reinforces the importance of necropsy as an essential tool for the differential diagnosis between degenerative, neoplastic, and vascular processes, especially in older dogs with chronic neurological manifestations. Furthermore, it highlights the educational and scientific role of post-mortem examination in veterinary practice, contributing to the improvement of knowledge about degenerative encephalopathies and to ethical decision-making based on animal welfare.

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References

BORRÀS, D. et al. Cognitive dysfunction syndrome in aging dogs: neuropathological similarities with Alzheimer’s disease. Veterinary Sciences, v. 11, n. 3, p. 412, 2024.

BRAMBELL, F. W. R. Report of the Technical Committee to Enquire into the Welfare of Animals kept under Intensive Livestock Husbandry Systems. London: HMSO, 1965.

CERNUDA-CERNUDA, R.; GARCÍA-FERNÁNDEZ, J. M.; MARTÍN, M. Neurodegenerative changes in aging dogs: correlation between amyloid deposition and cognitive dysfunction. Veterinary Pathology, v. 60, n. 4, p. 532–540, 2023.

CHAMBERS, C. et al. Prevalence and clinical features of neurodegenerative diseases in geriatric dogs. Animals (Basel), v. 13, n. 5, p. 789, 2023.

CUMMINGS, B. J.; SU, J. H.; HEAD, E.; COTMAN, C. W. The canine as an animal model of human aging and dementia. Progress in Neurobiology, v. 205, p. 102–118, 2021a.

CUMMINGS, B. J. et al. Brain tumors in domestic animals: clinicopathologic correlations. Journal of Veterinary Neurology, v. 34, n. 2, p. 233–245, 2021b.

FAST, R.; SCHÜTT, T. et al. Canine cognitive dysfunction: pathophysiology and clinical management. Frontiers in Veterinary Science, v. 10, p. 1123456, 2023.

FEFER, J. et al. Histopathological characterization of age-related brain atrophy in dogs. Pesquisa Veterinária Brasileira, v. 42, p. e07033, 2022.

HECKLER, M. C.; SAMPAIO, G. R.; MENDES, C. R. Age-related structural changes in the canine brain: a morphometric and histological study. Veterinary Research Communications, v. 44, n. 3, p. 189–197, 2020.

HEINSEN, H. et al. Neuropathological assessment of canine senile encephalopathy: advances in comparative neuropathology. Veterinary Pathology, v. 61, n. 1, p. 97–109, 2024.

KANG, M. H.; PARK, H. M. Canine cognitive dysfunction syndrome: recent insights into pathogenesis and diagnosis. Journal of Veterinary Science, v. 26, n. 2, p. e213, 2025.

KATINA, S.; RODRIGUES, A. P.; NAVARRO, P. L. Correlation between cognitive decline and motor impairment in geriatric dogs. Animals (MDPI), v. 13, n. 13, p. 2203, 2023.

LANDSBERG, G. M. Cognitive dysfunction syndrome in dogs and cats: current perspectives. Veterinary Clinics of North America: Small Animal Practice, v. 52, n. 1, p. 1–14, 2022.

LEE, J. H.; NAKAMURA, M.; TANAKA, S. Novel biomarkers for diagnosis of canine cognitive dysfunction: serum and CSF analysis. Frontiers in Veterinary Science, v. 12, p. 1458, 2025.

LIMA, F. R.; TORRES, B. R.; CAMPOS, R. P. Neurological diseases in geriatric dogs: prevalence and pathological correlations. Animals (MDPI), v. 14, n. 12, p. 1753, 2024.

NEILSON, J. C.; ADAMS, V. H.; DE LAHUNTA, A. Diagnostic challenges in geriatric canine neurology: differentiation of neoplastic and degenerative CNS disorders. Journal of Comparative Pathology, v. 210, p. 15–24, 2024.

OIE – ORGANIZAÇÃO MUNDIAL DE SAÚDE ANIMAL. Animal Welfare Standards and Guidelines. Paris: OIE, 2023.

SCHÜTT, T.; TOFT, N.; BERENDT, M. Cognitive dysfunction in canine aging: a comparative model for human neurodegenerative disease. Journal of Veterinary Behavior, v. 25, p. 73–80, 2018.