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Abstract
The objective of the present work is to promote a review of the main microbial markers for detection of colorectal cancer (CRC), as well as to explain the difficulties involved in their standardization. Several studies show the elevation of certain microorganisms to the detriment of the intestinal microbiome during the development of CRC and one of the reasons that favor them are virulence factors. Streptococcus galollyticus subs. gallolyticus and Clostridium symbosium are among the main microbial markers. However, isolates do not demonstrate the ideal sensitivity and specificity for CCR detection, and the result is optimized by associating some markers with the usual ones, such as human fecal hemoglobin (F-HB). These markers are promising, however, there is a need for further studies for their standardization.
References
EVELLYN et al. Câncer colorretal no brasil: aspectos topográficos e epidemiológicos. Centro Universitário de Anápolis – Unievangélica, Anápolis, Goiás, 2019.
VILLÉGER, R. et al. Microbial markers in colorectal cancer detection and/or prognosis. World J Gastroenterol , v. 24, n. 22, p. 2327. - 2347, 2018.
LOWENMARK, T. et al. Parvimonas micra as a putative non - invasive faecal biomarker for colorectal cancer. Sci Rep , v. 10, n. 1, p. 15250, 2020
HONG-XIE et al. Fecal Clostridium symbiosum for Noninvasive Detection of Early and Advanced Colorectal Cancer: Test and Validation Studies. Rev. Dicovery Science. V. 25, Pages 32-40, november 2017.
JIAN YANG, Dongfang Li, Zhenyu Yang, Wenkui Dai, Xin Feng, Yanhong Liu, Yiqi Jiang, Pingang Li, Yinhu Li, Bo Tang, Qian Zhou, Chuangzhao Qiu, Chao Zhang, Ximing Xu, Su Feng, Daxi Wang, Heping Wang, Wenjian Wang, Yuejie Zheng, Lin Zhang, Wenjie Wang, Ke Zhou, Shuaicheng Li & Peiwu Yu. Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families, Gut Microbes, 11:4, 918-929, 2020.
ZHANG et al. A comprehensive analysis of the microbiota composition and gene expression in colorectal câncer. BMC Microbiology, 20:308, 2020.
BOLEIJ et al. Novel Clues on the Specific Association of Streptococcus gallolyticus subsp gallolyticus With Colorectal Cancer. The Journal of Infectious Diseases, Volume 203, Issue 8, 15 April 2011, Pages 1101–1109
JUN XU et al. Alteration of the abundance of Parvimonas micra in the gut along the adenoma carcinoma sequence. Oncol Lett. 2020 Oct; 20(4): 106, 2020.
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