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Abstract
Obesity is characterized as a chronic disease in which the affected person has an accumulation of adipose tissue, beyond that it's being considered a public health pathology according to the World Health Organization (WHO). In this sense, the outline proposed by this expanded summary aims to clarify a relationship between obesity, chronic inflammation and associated comorbidities. Thus, we will detail the action of the main factors that coordinate these processes, such as adipokines, which are bioactive peptides secreted by adipocytes. These molecules may belong to the class of cytokines, as they are secreted by immune cells, such as macrophages. Among these, the main proteins acting in the inflammatory response that will be studied are: IL-6, TNF-α, leptin, resistin, C-reactive protein (CRP) (pro-inflammatory) and adiponectin (anti-inflammatory). Based on this clarification, we were able to list the main consequences arising from the imbalance in the systematic functioning of these derivatives that act with different mechanisms in the human body, in this case, in an individual affected by obesity. After that, we can understand that from these factors, new diseases called comorbidities will emerge, considering that they are directly linked to excess body fat.